British Journal of Pharmacology, published online Septemdoi: 10.1111/bph. The venom sac continues to pump venom through the sting into the wound. Therapeutic effects of bee venom and its major component, melittin, on atopic dermatitis in vivo and in vitro. A honey bee can sting only once and the stinger with the venom sac is detached from the bee’s body. It contains a mixture of enzymes, sugars, minerals, and amino acids. The findings were published online September 5 in the British Journal of Pharmacology. What is Bee Venom Bee venom is a bitter, colorless and an acidic liquid. “Our results suggest that bee venom and melittin would be suitable for epicutaneous application, as topical administration is often appropriate for the treatment of atopic dermatitis.” “We demonstrated that bee venom and melittin have immunomodulatory activity, and such activity was associated with the regulation of T helper cell differentiation, thereby ameliorating the inflammatory skin diseases caused by atopic dermatitis,” they said. Through studies conducted in mice and human cells, Professor Park and his colleagues from Catholic University of Daegu, Korea’s National Academy of Agricultural Science and Charles Sturt University found that bee venom and melittin suppress inflammation through various mechanisms on immune cells and inflammatory molecules. Melittin, the major component (50% of dry weight) of bee venom, is a small linear peptide composed of 26 amino acids. It contains various peptides, including melittin, apamin, adolapin, and mast cell degranulating peptide along with enzymes, biological amines, and nonpeptide components. “However, bee venom and melittin-mediated atopic dermatitis treatment has rarely been studied.”īee venom is a natural toxin produced by honeybees ( Apis mellifera). “There are several studies on natural materials or toxins, such as herbs, ginseng extract, and snake venom, for atopic dermatitis treatment,” said Catholic University of Daegu’s Professor Kwan-Kyu Park and co-authors. These therapies reduce inflammation, but they also cause various side effects. Many commercial formulations for the treatment of this disease are available in gels, creams, lotions, or ointments but show limited effectiveness.įurthermore, there are several treatment approaches for atopic dermatitis, such as topical glucocorticosteroids, emollients, phototherapies, calcineurin inhibitors, and immunosuppressants, such as cyclosporine A. Sharp / CC BY-SA 3.0.Ītopic dermatitis, commonly known as atopic eczema, is a multifactorial skin disease, with complex interactions of innate and adaptive immune responses based on a genetic, pharmacological, and psychological predisposition. 268.Hyun-Jin An et al found that bee venom and melittin possess potent anti-atopic activities. Al-Ahram Centre for Translation and Publication Cairo, Egypt: 1994. Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications. Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests. ![]() Wehbe R., Frangieh J., Rima M., El Obeid D., Sabatier J.M., Fajloun Z. Bee venom therapy: Potential mechanisms and therapeutic applications. Zhang S., Liu Y., Ye Y., Wang X.R., Lin L.T., Xiao L.Y., Zhou P., Shi G.X., Liu C.Z. Bee venom and hesperidin effectively mitigate complete Freund’s adjuvant-induced arthritis via immunomodulation and enhancement of antioxidant defense system. Finally, the products of bee venom available in markets are also demonstrated.īee venom bee venom products inflammatory and chronic diseases nanoparticles.Īhmed O., Fahim H., Mahmoud A., Eman Ahmed E.A. The review also summarizes the potential of venom loaded on nanoparticles as a drug delivery vehicle and its molecular mechanisms. The updated molecular mechanisms of actions of bee venom and its components are discussed in light of the previous updated publications. The present review aims to refer to the use of bee venom itself or its fractions in treating several diseases and counteracting drug toxicities as an alternative protocol of therapy. ![]() Many reports and publications have stated that bee venom and its constituents have multiple biological activities including anti-microbial, anti-protozoan, anti-cancer, anti-inflammatory, and anti-arthritic properties. Other reports used the active fractions of bee venom clinically or at labratory scale. Different research papers stated the possibility of using bee venom (a direct bee sting or in an injectable form) in treating several complications either in vivo or in vitro. Specifically, venom from honeybees ( Apis mellifera) contains many enzymes and peptides that are effective against various diseases. Insects of the order Hymenoptera have a defensive substance that contains many biologically active compounds.
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